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Derivation of toxicity equivalency factors for marine biotoxins associated with Bivalve Molluscs ArchiMer
Botana, Luis M.; Hess, Philipp; Munday, Rex; Nathalie, Arnich; Degrasse, Stacey L.; Feeley, Mark; Suzuki, Toshiyuki; Van Den Berg, Martin; Fattori, Vittorio; Gamarro, Esther Garrido; Tritscher, Angelika; Nakagawa, Rei; Karunasagar, Iddya.
Background Seafood toxins pose an important risk to human health, and maximum levels were imposed by regulatory authorities throughout the world. Several toxin groups are known, each one with many analogues of the major toxin. Regulatory limits are set to ensure that commercially available seafood is not contaminated with unsafe levels. Scope and Approach The mouse bioassay was used to measure the toxicity in seafood extracts to determine if a sample exceeded regulatory limits. The advantage of this approach was to provide an estimation of the total toxicity in the sample. As instrumental methods of analysis advance and serve as replacements to the mouse bioassay, the challenge is translating individual toxin concentrations into toxicity to determine...
Tipo: Text Palavras-chave: Marine toxins; Toxicity Equivalency Factors; FAO; WHO; Bivalve; Mollusc.
Ano: 2017 URL: http://archimer.ifremer.fr/doc/00358/46960/46874.pdf
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High resolution mass spectrometry for quantitative analysis and untargeted screening of algal toxins in mussels and passive samplers ArchiMer
Zendong, Suzie Zita; Mccarron, Pearse; Herrenknecht, Christine; Sibat, Manoella; Amzil, Zouher; Cole, Richard B.; Hess, Philipp.
Measurement of marine algal toxins has traditionally focussed on shellfish monitoring while, over the last decade, passive sampling has been introduced as a complementary tool for exploratory studies. Since 2011, liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been adopted as the EU reference method (No.15/2011) for detection and quantitation of lipophilic toxins. Traditional LC-MS approaches have been based on low-resolution mass spectrometry (LRMS), however, advances in instrument platforms have led to a heightened interest in the use of high-resolution mass spectrometry (HRMS) for toxin detection. This work describes the use of HRMS in combination with passive sampling as a progressive approach to marine algal toxin surveys. Experiments...
Tipo: Text Palavras-chave: Monitoring; Marine toxins; Passive sampling; SPATT; Matrix effects.
Ano: 2015 URL: http://archimer.ifremer.fr/doc/00277/38848/37388.pdf
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Les risques sanitaires liés à la présence d'Ostreopsis ovata dans les eaux de baignade ou d'activités nautiques ArchiMer
Kermarec, Florence; Dor, Frederic; Armengaud, Alexis; Charlet, Francis; Kantin, Roger; Sauzade, Didier; De Haro, Luc.
An initial surveillance system of Ostreopsis ovata was set Lip along the Mediterranean coast in the summer of 2007. To Strengthen and adapt this system, we reviewed the information available for a health risk assessment of this monocellular species of algae that produces palytoxin and is increasingly observed in the Mediterranean Sea. Since 2002, this species has been reported to be responsible for many human cases of irritation, Cough, fever and respiratory problems in Europe. It is not Currently possible to determine if palytoxin causes these health effects, which follow aerosol inhalation. Ingestion of contaminated seafood may lead to very serious poisoning, but no such case has yet been described in Europe. A "dose-response' relation cannot be...
Tipo: Text Palavras-chave: Risk assessment; Mediterranean Sea; Marine toxins; Algae; Toxines flore et faune marines; Mer Méditerranée; Évaluation du risque; Algues.
Ano: 2008 URL: http://archimer.ifremer.fr/doc/2008/publication-6164.pdf
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